Clinical significance of hepatitis B surface antigen mutants

Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described...

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Published inWorld journal of hepatology Vol. 7; no. 27; pp. 2729 - 2739
Main Authors Coppola, Nicola, Onorato, Lorenzo, Minichini, Carmine, Di Caprio, Giovanni, Starace, Mario, Sagnelli, Caterina, Sagnelli, Evangelista
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.11.2015
Subjects
escape;Immune
Hepatitis
infection;Vaccine
Review
virus
Vaccine escape
Immune escape hepatocellular carcinoma
Hepatitis B surface antigen mutants
Hepatitis B virus infection
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Summary:Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBs Ag, called the "a" determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBs Ag detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBs Ag mutants and their biological and clinical implications.
Bibliography:Hepatitis B virus infection;Vaccine escape;Immune
Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBs Ag, called the "a" determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBs Ag detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBs Ag mutants and their biological and clinical implications.
Nicola Coppola;Lorenzo Onorato;Carmine Minichini;Giovanni Di Caprio;Mario Starace;Caterina Sagnelli;Evangelista Sagnelli;Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples;Department of Clinical and Experimental Medicine and Surgery "F.Magrassi e A.Lanzara",Second University of Naples
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Telephone: +39-8-15666719 Fax: +39-8-15666013
Author contributions: Coppola N has contributed to conception of the paper and draft the article; Onorato L has analyzed the role of HBsAg mutants associated with HCC development; Minichini C has analyzed the HBV virology and HBsAg structure; Di Caprio G has analyzed the role of HBsAg mutants associated with immune escape; Starace M has analyzed the HBV virology and HBsAg structure; Sagnelli C has analyzed the role of HBsAg mutants associated with failed HBsAg detection; Sagnelli E has contributed to conception of the paper and draft the article.
Correspondence to: Nicola Coppola, MD, PhD, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via: L. Armanni 5, 80131 Naples, Italy. nicola.coppola@unina2.it
ISSN:1948-5182
1948-5182
DOI:10.4254/wjh.v7.i27.2729