Prognostic value of clinical characteristics and immunophenotypic biomarkers in 115 patients with primary central nervous system lymphoma

• Published in: Chinese medical journal Vol. 126; no. 3; pp. 482 - 487
• Main Authors: CHEN, Bo-bin, XU, Xiao-ping, SHEN, Lin, HAN, Tian-jie, LIN, Zhi-guang, CHEN, Zi, KANG, Hui, HUANG, Bo, LIN, Guo-wei
• Format: Journal Article
• Language: English
• Published: China Department of Hematology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China 01.02.2013
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Adult; Aged; B细胞淋巴瘤; Central Nervous System Neoplasms - metabolism; Central Nervous System Neoplasms - pathology; Cyclin D3 - metabolism; Cyclin E - metabolism; Female; Forkhead Transcription Factors - metabolism; Humans; Immunohistochemistry; LIM Domain Proteins - metabolism; Lymphoma - metabolism; Lymphoma - pathology; Male; Middle Aged; Prognosis; Proto-Oncogene Proteins - metabolism; Repressor Proteins - metabolism; Retrospective Studies; Young Adult; 中枢神经系统; 临床特点; 免疫标记; 原发性; 生物标志物; 细胞周期蛋白; 预后; Cyclin E; immunochemohistorical marker; prognosis; primary central nervous system lymphoma; Cyclin D3
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20120844

Background Clinical outcome in patients with primary central nervous lymphoma （PCNSL） is variable and poorly predictable. This study investigated the association of clinical features and immune markers with prognosis of patients with PCNSL. Methods One hundred and fifteen newly diagnosed PCNSL patients at the study institution were considered eligible for this study. Clinical characteristics and biochemical assay data were collected. Immunohistochemical staining of Cyclin D3, Cyclin E, Foxpl, and LMO2 were performed. All cases were followed-up regularly. Results The common sites of involvement were frontal lobe （54.8%） and thalamus （16.5%）. Diffuse large B-cell lymphoma composed of 96.5% of the cases. The median overall survival was 22 （4-41） months, and the 5-year survival rate was 22.8%. Age 〉65 years, serum globulin 〉40 g/L, large size of tumor, lymphocyte count ≥1×10^9/L, and expression of Cyclin D3 and Cyclin E were associated with poor prognosis of PCNSL. Expressions of Foxpl, LMO2, and CD44 were not related to the survival. Expression of Cyclin E, large tumor size, and high serum globulin were independent prognostic factors for PCNSL. Conclusions PCNSL prognosis is relatively poor. Age, high tumor burden, higher lymphocyte count, expression of Cyclin D3, and Cyclin E are inferior prognostic factors for PCNSL.