In Vivo Histocompatibility Evaluation of Polyurethane Membrane Modified by Superfine Silk-fibroin Powder

• Published in: Journal of Huazhong University of Science and Technology. Medical sciences Vol. 29; no. 4; pp. 508 - 511
• Main Author: 欧阳晨曦 许海叶 王维慈 杨红军 徐卫林
• Format: Journal Article
• Language: English
• Published: Heidelberg Huazhong University of Science and Technology 01.08.2009; Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China%Key Laboratory of Green Processing and Functional Textiles under Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, China%College of Textile, Donghua University, Shanghai 201620, China
• Subjects: Animals; Biocompatible Materials; Fibroins - chemistry; Implants, Experimental; Medicine; Medicine & Public Health; Membranes, Artificial; Mice; Muscle, Skeletal - surgery; Polyurethanes - chemistry; Powders; Random Allocation; Vascular Grafting; 组织相容性; 聚四氟乙烯材料; 聚氨酯薄膜; 膜改性; 蛋白粉; 超细丝; histocompatibility; polyurethane; superfine silk-fibroin powder; polytetrafluoroethylene; histoeompatibility
• ISSN: 1672-0733; 1993-1352
• DOI: 10.1007/s11596-009-0423-7

In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material. A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis.