Effectiveness of the near-infrared electronic endoscope for diagnosis of the depth of involvement of gastric cancers

• Published in: Gastrointestinal endoscopy Vol. 52; no. 6; pp. 755 - 762
• Main Authors: Iseki, Kazushige, Tatsuta, Masaharu, Iishi, Hiroyasu, Sakai, Noriko, Yano, Hiroyuki, Ishiguro, Shingo
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2000; Elsevier
• Subjects: Adult; Aged; Analysis of Variance; Biological and medical sciences; Coloring Agents; Digestive system. Abdomen; Endoscopy; Female; Gastric Mucosa - pathology; Gastroscopes; Gastroscopy - methods; Humans; Indocyanine Green; Infrared Rays; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Observer Variation; Probability; Prospective Studies; Sensitivity and Specificity; Severity of Illness Index; Stomach Neoplasms - diagnosis; Stomach Neoplasms - pathology; Characterization; Human; Near infrared radiation; Stomach; Clinical stage; Digestive diseases; Endoscopy; Gastroscopy; Malignant tumor; Gastric disease; Penetration depth
• ISSN: 0016-5107; 1097-6779
• DOI: 10.1067/mge.2000.110455

Background: Near-infrared light penetrates deeply into tissue but is not visible with a conventional endoscope. We developed a new infrared electronic endoscope system and evaluated its usefulness for assessing the depth of involvement of gastric cancers. Methods: A total of 61 patients with depressed or ulcer-ated gastric cancers underwent infrared endoscopy after intravenous injection of indocyanine green. Results: Intramucosal cancers were observed as tumors with or without a homogeneous tumor stain, whereas submucosal or deeper cancers were observed as tumors with an inhomogeneous stain or with pooling of the dye. Histologic examination showed staining properties of gastric cancers were significantly correlated with the characteristics of the vascular bed. The accuracy for depth of cancer invasion was 89% for mucosal cancers and 89% for submucosal or deeper cancers. Conclusion: Our new infrared electronic endoscope sys-tem was useful for distinguishing mucosal cancers from submucosal or deeper cancers either with or without ulcerative changes.