Comparison of serum levels of vitamin D and vitamin D-binding protein in normal, osteopenic and osteoporotic postmenopausal women

• Published in: Pakistan journal of medical sciences Vol. 35; no. 2; pp. 543 - 548
• Main Authors: Murad, Rafat, Mahboob, Tabassum, Rehman, Rehana, Baig, Rozeena
• Format: Journal Article
• Language: English
• Published: Pakistan Knowledge Bylanes 30.04.2019; AsiaNet Pakistan (Pvt) Ltd; Professional Medical Publications
• Subjects: Comparative analysis; Homeostasis; Hormone replacement therapy; Menopause; Metabolites; Original; Osteoporosis; Phosphates; Physiological aspects; Postmenopausal women; Protein binding; Proteins; Vitamin D; Vitamin D deficiency; Vitamin deficiency; Vitamins; Women; Post menopausal females; Vitamin D binding protein; Bone mineral density; Vitamin D
• ISSN: 1682-024X; 1681-715X
• DOI: 10.12669/pjms.35.2.714

To compare the serum levels of vitamin D, vitamin D binding protein (VDBP) calcium and phosphate in normal, osteopenic and osteoporotic postmenopausal women categorized on the basis of bone mineral density (BMD) scores. A cross sectional study carried out from May 2017 to August 2018. BMD measured by Dual energy X-ray Absorptiometry categorized women (aged 20- 70 years) into normal (n=37) (T score ≥ -1.0) osteopenic (n=25) (-2.5< T score, < -1) and osteoporotic (n= 26) (T score < -2.5) according to WHO classification. Serum concentrations of vitamin D, VDBP, calcium, phosphate analyzed by enzyme linked immunosorbent assay were compared by Analysis of Variance. In normal females higher levels of vitamin D and VDBP were observed [15.82 (8 - 69.18), 469.9 (269.57 - 875.55)] vs. osteopenic [(7.45 (4.66 - 15.1), 296.05 (232.58 - 420.23)] and osteoporotic women [(7.25 (3.97 - 17.49), 272.94 (202.23 - 351.24)]; [median interquartile range]; p value < 0.0001. Vitamin D and VDBP are linked with bone health and estimation of VDBP appears to be a valuable tool for the assessment of increased bone loss and possible risks of bone fractures especially in postmenopausal women.