Incidence of Mid-Term Prognostic Events in Patients With Acute Coronary Syndrome During the Late 2010s in 2 Tertiary Hospitals in a Rural Area of Japan　― A Temporal Comparison

• Published in: Circulation Reports Vol. 5; no. 5; pp. 198 - 209
• Main Authors: Yasuda, Yu, Ishiguchi, Hironori, Yamaguchi, Madoka, Murakami, Kei, Kinoshita, Natsu, Kato, Takayoshi, Yoshida, Masaaki, Imoto, Koji, Sonoyama, Kazuhiko, Kawabata, Tetsuya, Okamura, Takayuki, Endo, Akihiro, Kobayashi, Shigeki, Yano, Masafumi, Oda, Tsuyoshi, Tanabe, Kazuaki
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Circulation Society 10.05.2023
• Subjects: Acute coronary syndrome; Ischemic Heart Disease; Major adverse cardiovascular events; Original article; ST-elevation myocardial infarction; Major adverse cardiovascular events; Acute coronary syndrome; ST-elevation myocardial infarction
• ISSN: 2434-0790; 2434-0790
• DOI: 10.1253/circrep.CR-23-0029

Background: Data on the incidence of mid-term prognostic events in patients who developed acute coronary syndrome (ACS) in the late 2010s are scarce.Methods and Results: We retrospectively included and collected data for 889 patients with ACS (ST-elevation myocardial infarction [STEMI]/non-ST-elevation ACS [NSTE-ACS]) discharged alive from 2 tertiary hospitals in Izumo City, in rural Japan, between August 2009 and July 2018. Patients were divided into 3 time groups (T1: August 2009–July 2012; T2: August 2012–July 2015; T3: August 2015–July 2018). The cumulative incidence of major adverse cardiovascular events (MACE; comprising all-cause death, recurrent ACS, and stroke), major bleeding, and heart failure hospitalization within 2 years of discharge was compared among the 3 groups. The incidence of freedom from MACE was significantly higher in the T3 group than in the T1 and T2 groups (93 [95% confidence interval {CI} 90–96%] vs. 86% [95% CI 83–90] and 89% [95% CI 90–96], respectively; P=0.03). There was a tendency for a higher incidence of STEMI among patients in T3 (P=0.057). The incidence of NSTE-ACS was comparable among the 3 groups (P=0.31), as was the incidence of major bleeding and hospitalization for heart failure.Conclusions: The incidence of mid-term MACE in patients who developed ACS during the late 2010 s (2015–2018) was lower than that in prior periods (2009–2015).