Health related quality of life among patients with chronic graft-versus-host disease in China

• Published in: Chinese medical journal Vol. 126; no. 16; pp. 3048 - 3052
• Main Authors: Mo, Xiao-dong, Xu, Lan-ping, Liu, Dai-hong, Chen, Yu-hong, Zhang, Xiao-hui, Chen, Huan, Han, Wei, Wang, Yu, Wang, Feng-rong, Wang, Jing-zhi, Liu, Kai-yan, Huang, Xiao-jun
• Format: Journal Article
• Language: English
• Published: China Peking University People's Hospital & Institute of Hematology,Beijing Key laboratory of Hematopoitic Stem Cell Transplantation,Beijing 100044, China 01.08.2013
• Subjects: Adult; Chronic Disease; Female; Graft vs Host Disease - psychology; Humans; Male; Middle Aged; Quality of Life; Retrospective Studies; Severity of Illness Index; 中国; 异基因造血干细胞移植; 心理健康; 患者; 慢性; 生活品质; 生活质量; 移植物抗宿主病; National Institutes of Health consensus criteria; chronic graft-versus-host disease; health related quality of life
• ISSN: 0366-6999; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20122328

Background Chronic graft-versus-host disease （GVHD）,the commonest long-term complication after allogeneic hematopoietic stem cell transplantation （HSCT）,has a negative impact on patients＇ health related quality of life （HRQoL）.This study was designed to investigate the HRQoL in patients with chronic GVHD in China.Methods Two hundred and sixty-four patients with chronic GVHD who were ＞24 months post-HSCT and had been in continuous complete remission since HSCT were enrolled in this retrospective study.HRQoL was evaluated using an SF-36 questionnaire.Multivariate analysis was used to identify the factors that affect HRQoL in patients with chronic GVHD.Results HRQoL in patients categorized as having mild and moderate chronic GVHD was significantly better than in those in the severe category.In the moderate chronic GVHD category,markedly poorer HRQoL was observed in patients with both multiple organ involvement and more severe organ impairment than in those without these factors.According to multivariate analysis,chronic GVHD severity had the greatest significant negative impact on patients＇ HRQoL; whereas being female was associated with a negative impact on psychological health.Conclusion Chronic GVHD severity strongly correlates with negative impacts on patients＇ HRQoL.