Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action

Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy. Inhibitors of mycotoxin production are useful not only for developing effective methods to prevent mycotoxin contamination, but also for investigating the m...

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Published inBioscience, biotechnology, and biochemistry Vol. 80; no. 1; pp. 43 - 54
Main Authors Sakuda, Shohei, Yoshinari, Tomoya, Furukawa, Tomohiro, Jermnak, Usuma, Takagi, Keiko, Iimura, Kurin, Yamamoto, Toshiyoshi, Suzuki, Michio, Nagasawa, Hiromichi
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 2016
Subjects
aflatoxin
Aflatoxins - antagonists & inhibitors
Aflatoxins - biosynthesis
Aspergillus - drug effects
Aspergillus - pathogenicity
Aspergillus - physiology
Benzopyrans - pharmacology
biocontrol
Crops, Agricultural - drug effects
Crops, Agricultural - microbiology
Food Contamination - prevention & control
Fungicides, Industrial - pharmacology
Fusarium - drug effects
Fusarium - pathogenicity
Fusarium - physiology
Gallic Acid - analogs & derivatives
Gallic Acid - pharmacology
Humans
mycotoxin
Nucleosides - pharmacology
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Peptides, Cyclic - pharmacology
Plant Diseases - microbiology
precocene
Structure-Activity Relationship
trichothecene
Trichothecenes - antagonists & inhibitors
Trichothecenes - biosynthesis
mycotoxin
aflatoxin
biocontrol
trichothecene
precocene
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Summary:Mycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy. Inhibitors of mycotoxin production are useful not only for developing effective methods to prevent mycotoxin contamination, but also for investigating the molecular mechanisms of secondary metabolite production by fungi. We have been searching for mycotoxin production inhibitors among natural products and investigating their modes of action. In this article, we review aflatoxin and trichothecene production inhibitors, including our works on blasticidin S, methyl syringate, cyclo(l-Ala-l-Pro), respiration inhibitors, and precocene II.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2015.1086261