Facile fabrication of spongy nanofibrous scaffold for tissue engineering applications

[Display omitted] •Spongy and fluffy type nanofibrous scaffold is fabricated.•Lactic acid assisted the formation of fluffy architecture.•Cells were infiltrated throughout the scaffold on the fluffy type scaffold.•Fluffy scaffold enhanced the cell proliferation and growth. Herein, we present a novel...

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Bibliographic Details
Published inMaterials letters Vol. 219; pp. 119 - 122
Main Authors Hwang, Tae In, Maharjan, Bikendra, Tiwari, Arjun Prasad, Lee, Sunny, Joshi, Mahesh Kumar, Park, Chan Hee, Kim, Cheol Sang
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 15.05.2018
Elsevier BV
Subjects
Biocompatibility
Biomimetics
Cell growth
Cell infiltration and growth
Cells
Density
Digital imaging
Electrospinning
Emission analysis
Field emission microscopy
Infrared radiation
Lactic acid
Leaching
Materials science
Nanofiber
Regeneration
Scaffold
Scaffolds
Thermogravimetric analysis
Tissue engineering
Electrospinning
Nanofiber
Cell infiltration and growth
Scaffold
Tissue engineering
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Summary:[Display omitted] •Spongy and fluffy type nanofibrous scaffold is fabricated.•Lactic acid assisted the formation of fluffy architecture.•Cells were infiltrated throughout the scaffold on the fluffy type scaffold.•Fluffy scaffold enhanced the cell proliferation and growth. Herein, we present a novel strategy to fabricate high porous fluffy type Poly (L-lactide) (PLA) nanofibrous scaffold for tissue regeneration. Low-density nanofibrous scaffold was fabricated by electrospinning the blend of PLA and lactic acid (LA), followed by selective leaching of LA. Digital images, Field Emission Scanning Electron Microscope (FE-SEM) images, Infra-red (IR) spectra, Thermogravimetric analysis (TGA) curves revealed the formation of the low density biomimetic nanofibrous mesh. In vitro cell compatibility results indicated that as-fabricated PLA nanofibrous scaffold enhanced the cell proliferation and growth compared to the corresponding two-dimensional nanofibrous scaffold. Furthermore, confocal microscopy images showed that cells seeded on the fluffy type nanofibrous mesh infiltrated throughout the depth of the scaffold, compared to no penetrating growth for the two-dimensional scaffold. The fabrication of such fascinating materials may provide new insights into the design and development of the low density nanofibrous scaffolds for various tissue engineering applications.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2018.02.040