Biofilm tolerance, resistance and infections increasing threat of public health

Microbial biofilms can cause chronic infection. In the clinical setting, the biofilm-related infections usually persist and reoccur; the main reason is the increased antibiotic resistance of biofilms. Traditional antibiotic therapy is not effective and might increase the threat of antibiotic resista...

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Published inMicrobial cell Vol. 10; no. 11; pp. 233 - 247
Main Authors Yang, Shanshan, Li, Xinfei, Cang, Weihe, Mu, Delun, Ji, Shuaiqi, An, Yuejia, Wu, Rina, Wu, Junrui
Format Journal Article
LanguageEnglish
Published Shared Science Publishers OG 06.11.2023
Subjects
Biofilm
Diseases
Intervention
Resistance
Review
Tolerance
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Summary:Microbial biofilms can cause chronic infection. In the clinical setting, the biofilm-related infections usually persist and reoccur; the main reason is the increased antibiotic resistance of biofilms. Traditional antibiotic therapy is not effective and might increase the threat of antibiotic resistance to public health. Therefore, it is urgent to study the tolerance and resistance mechanism of biofilms to antibiotics and find effective therapies for biofilm-related infections. The tolerance mechanism and host reaction of biofilm to antibiotics are reviewed, and bacterial biofilm related diseases formed by human pathogens are discussed thoroughly. The review also explored the role of biofilms in the development of bacterial resistance mechanisms and proposed therapeutic intervention strategies for biofilm related diseases.
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Conflict of Interest: The authors declare no conflict of interest.
Please cite this article as: Shanshan Yang, Xinfei Li, Weihe Cang, Delun Mu, Shuaiqi Ji, Yuejia An, Rina Wu and Junrui Wu (2023). Biofilm tolerance, resistance and infections increasing threat of public health. Microbial Cell 10(11): 233-247. doi: 10.15698/mic2023.11.807
ISSN:2311-2638
2311-2638
DOI:10.15698/mic2023.11.807