Excess melanocytic nevi in children with renal allografts
Background: Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk. Objective: This study determines the prevalence of melanocytic nevi in children who have received renal allografts...
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Published in | Journal of the American Academy of Dermatology Vol. 28; no. 1; pp. 51 - 55 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
1993
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Background:
Renal allograft transplantation is associated with an increased incidence of malignant melanoma. The development of excess melanocytic nevi may be an indicator of this risk.
Objective:
This study determines the prevalence of melanocytic nevi in children who have received renal allografts.
Methods:
Total and regional melanocytic nevi counts were made in 38 children (27 boys, 11 girls) with a renal allograft and in 38 individually age- and sex-matched healthy controls; counts were related to age, sex, skin type, and duration of immunosuppression.
Results:
There was a significant increase in the total number of nevi in the renal transplant group compared with the control group (
p < 0.05), with most marked increases occurring on the back and at acral sites. A strong positive correlation between nevi count and duration of immunosuppression independent of age was observed (
p < 0.005).
Conclusion:
Excess numbers of melanoeytic nevi occur in children with renal allografts. These patients constitute a risk group for malignant melanoma and require continued assessment. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0190-9622 1097-6787 |
DOI: | 10.1016/0190-9622(93)70008-H |