Risk factors of knee osteoarthritis: A case-control study

• Published in: Pakistan journal of medical sciences Vol. 35; no. 3; pp. 636 - 640
• Main Authors: Moghimi, Nasrin, Rahmani, Khaled, Delpisheh, Ali, Saidi, Afshin, Azadi, Namam Ali, Afkhamzadeh, Abdorrahim
• Format: Journal Article
• Language: English
• Published: Pakistan Knowledge Bylanes 30.06.2019; AsiaNet Pakistan (Pvt) Ltd; Professional Medical Publications
• Subjects: Arthritis; Chronic illnesses; Diabetes; Disease; Elderly; Females; Fractures; Fractures (Injuries); Genetic disorders; Hypertension; Infection; Medical research; Obesity; Original; Osteoarthritis; Pain; Resveratrol; Rheumatic diseases; Rheumatoid factor; Risk factors; Smoking; Standard deviation; Studies; Tumors; Variables; Iran; Kurdistan; COPCORD study; Risk factors; Knee osteoarthritis
• ISSN: 1682-024X; 1681-715X
• DOI: 10.12669/pjms.35.3.277

Knee osteoarthritis is one of the most common rheumatologic problems. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I. Using data from the 2012 COPCORD study, stage-I that was conducted in Sanandaj, northwestern of Iran, we runned a case-control study in 2014-2015. Cases were 700 knee osteoarthritis using American College of Rheumatology (ACR) criteria, frequency matched with 700 healthy controls that were randomly selected from the general population. In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P <0.001), lodging (living in highland vs. plain) (P <0.001), type of used toilet (regular vs. toilet) (P <0.001), history of using high-heeled shoes (>3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P <0.001) and history of pain and swelling (lasting for one months) (P = 0.04). Living in highland area, using regular toilet, having knee injury and lower limb fracture in the past were most significant associated factors with occurrence of knee osteoarthritis.