Collective experiences of adventitious viruses of animal-derived raw materials and what can be done about them

Contamination of animal-derived raw materials with viruses, mycoplasmas, bacteria and fungi is common. These contaminants can interfere with the diagnosis of viral infection, and vaccines produced using infected cell cultures could lead to seroconversion or disease in the vaccinated animal. The puri...

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Published inCytotechnology (Dordrecht) Vol. 28; no. 1-3; pp. 43 - 48
Main Authors Wessman, S J, Levings, R L
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.11.1998
Kluwer Academic Publishers
Subjects
Bovine viral diarrhea virus
Contaminants
Contamination
Diarrhea
Seroconversion
Vaccines
Viruses
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Summary:Contamination of animal-derived raw materials with viruses, mycoplasmas, bacteria and fungi is common. These contaminants can interfere with the diagnosis of viral infection, and vaccines produced using infected cell cultures could lead to seroconversion or disease in the vaccinated animal. The purity, safety and efficacy of viral vaccines requires testing of the ingredients, cell substrates and final product. Methods for detection of viruses, especially bovine viral diarrhea virus, in nutrient serum, cell cultures, seed viruses and viral vaccines, and the frequency of their detection at the Center for Veterinary Biologics are discussed.
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ISSN:0920-9069
1573-0778
DOI:10.1023/A:1008005026243