Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population： a case-control study

• Published in: Chinese medical journal Vol. 126; no. 23; pp. 4403 - 4408
• Main Authors: GONG, Yi, SHI, Guo-chao, WAN, Huan-ying, YANG, Kun, PAN, Chun-ming, CHENG, Qi-jian, DAI, Ran-ran, LI, Qing-yun, LI, Min, ZHOU, Min, GUO, Yi
• Format: Journal Article
• Language: English
• Published: China Department of Respiratory Disease, Huashan Hospital, Fudan University, Shanghai 200040, China%Department of Pulmonary Medicine Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China%State Key Laboratory of Medical Genomics, Molecular Medicine Center Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 05.12.2013
• Subjects: Adult; Aged; Asian Continental Ancestry Group - genetics; Case-Control Studies; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Genotype; Haplotypes - genetics; Humans; Interleukin-13 - genetics; Linkage Disequilibrium - genetics; Male; Middle Aged; Polymorphism, Single Nucleotide - genetics; Pulmonary Disease, Chronic Obstructive - genetics; 中国南方; 关联; 基因分型; 慢性阻塞性肺疾病; 慢性阻塞性肺病; 汉族人群; 病例; 白细胞介素; gene polymorphism; case-control study; interleukin-13; chronic obstructive pulmonary disease
• ISSN: 0366-6999; 2542-5641; 2542-5641
• DOI: 10.3760/cma.j.issn.0366-6999.20130225

Background Interleukin-13 （IL-13） has been implicated to be responsible for recruitment of inflammatory cells from the blood to the lung,regulation of matrix metalloproteinase and induction of mucin production and secretion in chronic obstructive pulmonary disease （COPD）.We determined plasma IL-13 levels in patients with COPD and investigated its association with common polymorphisms of IL-13 gene in a case-control study.Methods We genotyped 160 cases and 175 control subjects in a local hospital using Mass-ArrayTM Technology Platform then tested the association of four SNPs in IL-13 （rs1295685,rs1800925,rs1881457,rs20541） with COPD,and then determined plasma IL-13 levels in patients with COPD and controls.Results Association was found between IL-13 gene SNPs （rs20541 and rs1800925） and an increased risk of COPD.By linkage disequilibrium （LD） analysis,two blocks （rs1881457 and rs1800925; rs20541 and rs1295685） were found.The risk of COPD was found associated with the IL-13 gene polymorphism among southern Chinese Han population.Plasma IL-13 level was increased in COPD patients compared with controls.Conclusions The polymorphism of the IL-13 gene is associated with an increased risk of COPD in southern Chinese Han population.Plasma IL-13 levels were found elevated in patients with COPD.