Anti-inflammatory and cytotoxic withanolides from Physalis minima

• Published in: Phytochemistry (Oxford) Vol. 155; pp. 164 - 170
• Main Authors: Wu, Jiangping, Li, Xia, Zhao, Jianping, Wang, Ruijuan, Xia, Zifei, Li, Xiaoran, Liu, Yanli, Xu, Qiongming, Khan, Ikhlas A., Yang, Shilin
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.11.2018; Elsevier
• Subjects: Anti-inflammatory; Biochemistry & Molecular Biology; Cytotoxic activity; Life Sciences & Biomedicine; Physalis minima L. (Solanaceae); Plant Sciences; Science & Technology; Withanolides; Withanolides; Anti-inflammatory; Physalis minima L. (Solanaceae); Cytotoxic activity; AERIAL PARTS; ANGULATA; NITRIC-OXIDE; TRYPANOCIDAL CONSTITUENTS
• ISSN: 0031-9422; 1873-3700
• DOI: 10.1016/j.phytochem.2018.08.009

Six undescribed withanolides were isolated and characterized during the investigation of anti-inflammatory and cytotoxic constituents from the whole plants of Physalis minima L. Their structures were elucidated by extensive spectroscopic analyses (IR, UV, HR-ESI-MS, 1D-NMR, and 2D-NMR), and their anti-inflammatory and cytotoxic activities were evaluated in vitro. All the compounds exhibited anti-inflammatory ability via inhibiting the production of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. Moderate cytotoxic activities against A549 lung adenocarcinoma cells, SMMC-7721 hepatic carcinoma cells and MCF-7 breast cancer cells with IC50 values in the range of 40.01–82.17 μM were observed for these withanolides. [Display omitted] •Six undescribed withanolides were isolated from the whole plants of Physalis minima L.•Their structures were elucidated by spectroscopic techniques.•All these withanolides exhibited both anti-inflammatory and moderate cytotoxic activities.