Paternal occupational exposures and embryo implantation rates after IVF

• Published in: Fertility and sterility Vol. 74; no. 4; pp. 690 - 695
• Main Authors: Tielemans, Erik, van Kooij, Roelof, Looman, Caspar, Burdorf, Alex, te Velde, Egbert, Heederik, Dick
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2000; Elsevier Science
• Subjects: Adult; Biological and medical sciences; Birth control; Cohort Studies; Embryo Implantation; Embryo Transfer; Female; Fertilization in Vitro; Gynecology. Andrology. Obstetrics; Humans; Implantation; in vitro fertilization; Male; Medical sciences; Netherlands; Occupational Exposure - adverse effects; occupational exposures; Paternal Exposure - adverse effects; Pesticides - adverse effects; Pregnancy; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Solvents - adverse effects; Sterility. Assisted procreation; Surveys and Questionnaires; Netherlands; in vitro fertilization; Implantation; occupational exposures; embryo transfer; Pregnancy; Solvent effect; In vitro fertilization embryo transfer; Human; Embryo transfer; Organic solvent; Ovum implantation; Toxicity; Assisted procreation; Female; Occupational exposure; Father
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(00)00720-2

Objective: To investigate any influence of paternal occupational exposures on implantation rates after IVF. Design: Cohort study of couples who sought IVF treatment. Setting: University Hospital Utrecht, The Netherlands. Patient(s): The study population was composed of 726 couples pursuing IVF treatment. Intervention(s): Only the earliest IVF treatment cycle with ET was selected for the analysis. All couples filled in a generic questionnaire on lifestyle factors and details about their occupation. In addition, more detailed exposure information was obtained for pesticides with use of job-specific questionnaires and a subsequent telephone interview. Main Outcome Measure(s): The implantation rate was defined as the number of gestational sacs seen with ultrasound at 6–7 weeks of pregnancy, divided by the number of embryos replaced. Result(s): A significantly reduced implantation rate was seen among couples with male partners working in occupations with presumably high levels of organic solvent exposure. Conversely, paternal pesticide exposure was significantly associated with an increased implantation rate. Paternal exposures to metal dust or fumes and welding fumes were not related to the probability of implantation. Conclusion(s): The findings suggested that paternal organic solvent exposure decreased the implantation rate among couples undergoing IVF-ET treatment.