Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the exc...

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Published inNanoscale Vol. 6; no. 5; pp. 2929 - 2936
Main Authors Staedler, Davide, Magouroux, Thibaud, Passemard, Solène, Schwung, Sebastian, Dubled, Marc, Schneiter, Guillaume Stéphane, Rytz, Daniel, Gerber-Lemaire, Sandrine, Bonacina, Luigi, Wolf, Jean-Pierre
Format Journal Article
LanguageEnglish
Published England 07.03.2014
Subjects
Biotechnology
Cell Line, Tumor
Cell Survival - drug effects
Deoxyribonucleic acid
DNA - chemistry
DNA - metabolism
Harmonics
Humans
Infrared
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Optical data processing
Photons
Photosensitizing Agents - chemistry
Photosensitizing Agents - toxicity
Reactive Oxygen Species - metabolism
Second harmonic generation
Tuning
Ultraviolet Rays
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Abstract A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules. A theranostic approach based on second harmonic generation by nanoparticles is demonstrated on malignant human cells.
AbstractList A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.
A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules. A theranostic approach based on second harmonic generation by nanoparticles is demonstrated on malignant human cells.
Author Bonacina, Luigi
Gerber-Lemaire, Sandrine
Rytz, Daniel
Wolf, Jean-Pierre
Magouroux, Thibaud
Schneiter, Guillaume Stéphane
Dubled, Marc
Staedler, Davide
Schwung, Sebastian
Passemard, Solène
AuthorAffiliation EPFL
Université de Savoie
SYMME
FEE Gmbh
Institute of Chemical Sciences and Engineering
GAP-Biophotonics
Université de Genève
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CitedBy_id crossref_primary_10_1016_j_nano_2014_12_018
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Snippet A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines...
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SubjectTerms Biotechnology
Cell Line, Tumor
Cell Survival - drug effects
Deoxyribonucleic acid
DNA - chemistry
DNA - metabolism
Harmonics
Humans
Infrared
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Optical data processing
Photons
Photosensitizing Agents - chemistry
Photosensitizing Agents - toxicity
Reactive Oxygen Species - metabolism
Second harmonic generation
Tuning
Ultraviolet Rays
Title Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples
URI https://www.ncbi.nlm.nih.gov/pubmed/24477750
https://search.proquest.com/docview/1499141190
https://search.proquest.com/docview/1512331902
https://search.proquest.com/docview/1671618700
Volume 6
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