Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the exc...

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Bibliographic Details
Published inNanoscale Vol. 6; no. 5; pp. 2929 - 2936
Main Authors Staedler, Davide, Magouroux, Thibaud, Passemard, Solène, Schwung, Sebastian, Dubled, Marc, Schneiter, Guillaume Stéphane, Rytz, Daniel, Gerber-Lemaire, Sandrine, Bonacina, Luigi, Wolf, Jean-Pierre
Format Journal Article
LanguageEnglish
Published England 07.03.2014
Subjects
Biotechnology
Cell Line, Tumor
Cell Survival - drug effects
Deoxyribonucleic acid
DNA - chemistry
DNA - metabolism
Harmonics
Humans
Infrared
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Optical data processing
Photons
Photosensitizing Agents - chemistry
Photosensitizing Agents - toxicity
Reactive Oxygen Species - metabolism
Second harmonic generation
Tuning
Ultraviolet Rays
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Summary:A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules. A theranostic approach based on second harmonic generation by nanoparticles is demonstrated on malignant human cells.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:2040-3364
2040-3372
DOI:10.1039/c3nr05897b