Miniaturized sample preparation methods for saliva analysis

• Published in: Bioanalysis Vol. 11; no. 2; pp. 119 - 148
• Main Authors: Seidi, Shahram, Rezazadeh, Maryam, Alizadeh, Reza
• Format: Journal Article
• Language: English
• Published: England Future Science Ltd 01.01.2019; Newlands Press
• Subjects: liquid phase microextraction; membrane based microextraction; microextraction; Saliva; sample preparation; solid phase microextraction; saliva; solid phase microextraction; membrane based microextraction; microextraction; sample preparation; liquid phase microextraction
• ISSN: 1757-6180; 1757-6199
• DOI: 10.4155/bio-2018-0160

Saliva, as the first body fluid encountering with the exogenous materials, has good correlation with blood and plays an important role in bioanalysis. However, saliva has not been studied as much as the other biological fluids mainly due to restricted access to its large volumes. In recent years, there is a growing interest for saliva analysis owing to the emergence of miniaturized sample preparation methods. The purpose of this paper is to review all microextraction methods and their principles of operation. In the following, we examine the methods used to analyze saliva up to now and discuss the potential of the other microextraction methods for saliva analysis to encourage research groups for more focus on this important subject area.