Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products

• Published in: Journal of applied physiology (1985) Vol. 88; no. 5; pp. 1558 - 1564
• Main Authors: van den Burg, P. J. M, Hospers, J. E. H, Mosterd, W. L, Bouma, B. N, Huisveld, I. A
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.05.2000; American Physiological Society
• Subjects: Adult; Aging; Aging - blood; Aging - physiology; Anatomy & physiology; Anthropometry; Biological and medical sciences; Blood coagulation. Blood cells; Blood Volume; Exercise; Fibrinolysis - physiology; Fundamental and applied biological sciences. Psychology; General aspects, investigation methods, hemostasis, fibrinolysis; Hemostasis; Humans; Male; Men; Middle Aged; Molecular and cellular biology; Physical Exertion - physiology; Physical Fitness; Maximal physical exercise; Human; Blood coagulation; Physical fitness; Senescence; Bicycle ergometer; Fibrinolysis factor; Fibrinolysis; Recovery
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.2000.88.5.1558

1  Department of Medical Physiology and Sports Medicine and 2  Department of Hematology, University of Utrecht, 3508 TA Utrecht, The Netherlands The influence of age on training-induced changes in resting and stimulated hemostatic potential was studied in three age categories (Cat I-III; 20-30 yr, 35-45 yr, and 50-60 yr, respectively) of sedentary men before and after 12 wk of training. Coagulation, fibrinolytic activity, and activation markers (reflecting fibrin formation and degradation) were determined. Physical conditioning resulted in a more pronounced increase in von Willebrand factor (vWF) and factor VIII clotting activity (FVIII:c) in Cat I and II and a more pronounced shortening of the activated partial thromboplastin time in all categories at maximal exertion and during recovery. Enhanced increases in tissue-type plasminogen activator (t-PA) antigen and activity and single-chain (sc) urokinase-type plasminogen activator (u-PA) at maximal exercise and 5 min of recovery were observed in all age groups after training. The effects on FVIII:c, vWF, and scu-PA were most pronounced in the youngest age group (Cat I). Increases in the marker of thrombin generation were highest in Cat III; no effect was seen on thrombin-antithrombin complex, plasmin-antiplasmin complex, and D-dimer in any of the age groups. We concluded that training enhances both coagulation and fibrinolytic potential during strenuous exercise. The effect on FVIII/vWF and t-PA/u-PA is most pronounced in younger individuals, whereas thrombin formation is most pronounced in older individuals. activation markers; coagulation; fibrinolysis