Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling

Type I interferons are imperative in maintaining a defense against viral infection. These cytokines also play an important role in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. In the present article, we attempt to analyze the a...

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Published inSeminars in cancer biology Vol. 10; no. 2; pp. 83 - 92
Main Authors Prejean, Christine, Colamonici, Oscar R.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2000
Subjects
Animals
Humans
interferon / receptor / signaling / domains
interferon receptors
Jak kinase
Janus Kinase 1
Membrane Proteins
Phosphorylation - drug effects
Protein-Tyrosine Kinases - metabolism
Receptor, Interferon alpha-beta
Receptors, Interferon - physiology
Signal Transduction - physiology
Stat protein
interferon / receptor / signaling / domains
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Summary:Type I interferons are imperative in maintaining a defense against viral infection. These cytokines also play an important role in the control of cell proliferation. These effects are triggered by ligand binding to a specific cell surface receptor. In the present article, we attempt to analyze the advances made in the last four years on type I interferon signaling. This review will focus on the contribution of the cytoplasmic domain of the α and β L chains of the receptor to the activation of the Jak-Stat pathway. We also analyze the possible role of other pathways in interferon signaling.
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ISSN:1044-579X
1096-3650
DOI:10.1006/scbi.2000.0311