Functional annotation of the microRNA-mediated network in gigantomastia by integrating microRNA and mRNA expression profiling

Background Gigantomastia is the overdevelopment of the female mammary gland, and it causes great physiological and psychological burdens to patients. A better understanding of the molecular mechanisms involved in gigantomastia is needed to develop less invasive and more effective medical treatments....

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Published inChinese medical journal Vol. 126; no. 4; pp. 740 - 746
Main Authors Li, Jing-yi, Mu, Da-li, Mu, Lan-hua, Xin, Min-qiang, Luan, Jie
Format Journal Article
LanguageEnglish
Published China Center for Mammoplasty and Reconstruction, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100144, China 20.02.2013
Subjects
Adult
Breast - abnormalities
Female
Gene Expression Profiling - methods
Humans
Hypertrophy - genetics
Male
microRNA
MicroRNAs - genetics
miRNAs
mRNA表达
RNA, Messenger - genetics
RNA介导
乳腺癌
功能注释
小分子
表达谱
miRNA
mRNA
gigantomastia
network
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Summary:Background Gigantomastia is the overdevelopment of the female mammary gland, and it causes great physiological and psychological burdens to patients. A better understanding of the molecular mechanisms involved in gigantomastia is needed to develop less invasive and more effective medical treatments. MicroRNA （miRNA） is a class of small noncoding RNAs that play an important regulatory role at the post-transcriptional level. These miRNAs are known to be involved in many diseases, including breast cancer; however, the relationship between miRNA and gigantomastia is largely unknown. Methods Whole genome-wide expression of miRNA and mRNA in gigantomastia was detected using microarray and functional annotation was performed based on the altered expression of miRNAs and mRNAs. Results We found many miRNAs and mRNAs to be significantly differentially expressed in gigantomastia compared with normal breast tissues. Functional annotation analysis indicated that APK, Wnt, and Neurotrophin signaling pathways may participate in gigantomastia. Conclusion This study addresses the need for better diagnosis and treatment of gigantomastia by providing new insight into the molecular mechanisms underlying this disease.
Bibliography:Background Gigantomastia is the overdevelopment of the female mammary gland, and it causes great physiological and psychological burdens to patients. A better understanding of the molecular mechanisms involved in gigantomastia is needed to develop less invasive and more effective medical treatments. MicroRNA （miRNA） is a class of small noncoding RNAs that play an important regulatory role at the post-transcriptional level. These miRNAs are known to be involved in many diseases, including breast cancer; however, the relationship between miRNA and gigantomastia is largely unknown. Methods Whole genome-wide expression of miRNA and mRNA in gigantomastia was detected using microarray and functional annotation was performed based on the altered expression of miRNAs and mRNAs. Results We found many miRNAs and mRNAs to be significantly differentially expressed in gigantomastia compared with normal breast tissues. Functional annotation analysis indicated that APK, Wnt, and Neurotrophin signaling pathways may participate in gigantomastia. Conclusion This study addresses the need for better diagnosis and treatment of gigantomastia by providing new insight into the molecular mechanisms underlying this disease.
gigantomastia; miRNA; mRNA; network
11-2154/R
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20121419