Hepatocellular carcinoma:A comprehensive review

Hepatocellular carcinoma(HCC) is rapidly becoming one of the most prevalent cancers worldwide. With a rising rate, it is a prominent source of mortality. Patients with advanced fibrosis, predominantly cirrhosis and hepatitis B are predisposed to developing HCC. Individuals withchronic hepatitis B an...

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Published inWorld journal of hepatology Vol. 7; no. 26; pp. 2648 - 2663
Main Author Waller, Lisa P
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 18.11.2015
Subjects
Criteria;S
Liver
Review
transplantation;Hepatectomy;Milan
University of California San Francisco Criteria
Sorafenib
Transarterial chemoembolization
Living donor liver transplantation
Expansion Milan Criteria
Hepatocellular carcinoma
Mammalian target of rapamycin inhibitors
Salvage liver transplantation
Hepatectomy
Liver transplantation
Milan Criteria
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ISSN1948-5182
1948-5182
DOI10.4254/wjh.v7.i26.2648

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Summary:Hepatocellular carcinoma(HCC) is rapidly becoming one of the most prevalent cancers worldwide. With a rising rate, it is a prominent source of mortality. Patients with advanced fibrosis, predominantly cirrhosis and hepatitis B are predisposed to developing HCC. Individuals withchronic hepatitis B and C infections are most commonly afflicted. Different therapeutic options, including liver resection, transplantation, systemic and local therapy, must be tailored to each patient. Liver transplantation offers leading results to achieve a cure. The Milan criteria is acknowledged as the model to classify the individuals that meet requirements to undergo transplantation. Mean survival remains suboptimal because of long waiting times and limited donor organ resources. Recent debates involve expansion of these criteria to create options for patients with HCC to increase overall survival.
Bibliography:Liver transplantation;Hepatectomy;Milan Criteria;S
Hepatocellular carcinoma(HCC) is rapidly becoming one of the most prevalent cancers worldwide. With a rising rate, it is a prominent source of mortality. Patients with advanced fibrosis, predominantly cirrhosis and hepatitis B are predisposed to developing HCC. Individuals withchronic hepatitis B and C infections are most commonly afflicted. Different therapeutic options, including liver resection, transplantation, systemic and local therapy, must be tailored to each patient. Liver transplantation offers leading results to achieve a cure. The Milan criteria is acknowledged as the model to classify the individuals that meet requirements to undergo transplantation. Mean survival remains suboptimal because of long waiting times and limited donor organ resources. Recent debates involve expansion of these criteria to create options for patients with HCC to increase overall survival.
Lisa P Waller;Vrushak Deshpande;Nikolaos Pyrsopoulos;Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School
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Correspondence to: Nikolaos Pyrsopoulos, MD, PhD, MBA, FACP, AGAF, Chief of Division of Gastroenterology and Hepatology, Medical Director of Liver Transplantation, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, MSB H538, 185 South Orange Avenue, Newark, NJ 07103, United States. pyrsopni@njms.rutgers.edu
Telephone: +1-973-9725252 Fax: +1-973-9723144
Author contributions: All three authors had been involved in creating the paper.
ISSN:1948-5182
1948-5182
DOI:10.4254/wjh.v7.i26.2648