Reactive Oxygen Species (ROS): involvement in bovine follicular cysts etiopathogenesis

• Published in: Immunopharmacology and immunotoxicology Vol. 31; no. 4; pp. 631 - 635
• Main Authors: Rizzo, Annalisa, Minoia, Giuseppe, Trisolini, Carmelinda, Mutinati, Maddalena, Spedicato, Massimo, Jirillo, Felicita, Sciorsci, Raffaele Luigi
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.12.2009; Taylor & Francis
• Subjects: Animals; apoptosis; bovine; Cattle; Cattle Diseases - etiology; Cattle Diseases - metabolism; Cattle Diseases - pathology; Female; Follicular Cyst - metabolism; Follicular Cyst - pathology; follicular cysts; Follicular Fluid - metabolism; Ovarian Follicle - metabolism; Ovarian Follicle - pathology; ovulation; Reactive Oxygen Species; Reactive Oxygen Species - metabolism
• ISSN: 0892-3973; 1532-2513
• DOI: 10.3109/08923970902932962

Ovulation is compared to an acute inflammatory process during which vasoactive agents, prostanoids, leukotrienes and Reactive Oxygen Species (ROS) develop. The aim of this study was to evaluate the levels of ROS in cystic and follicular fluid, in order to establish their involvement in the etiopathogenesis of Cystic Ovarian Follicle (COF) in dairy cows. The study was conducted in 30 healthy cows (group C) and 30 cows affected by COF (group COF). The fluid of follicular cysts and of preovulatory follicles was drawn by means of ultrasound guided aspiration from the cows of both groups. The fluid obtained was analyzed by a photometric analytical system to detect ROS level. ROS concentration was statistically lower in the cystic fluid than in the follicular one (62.4 ± 13.36 U.Carr vs. 84.89 ± 26.99 U.Carr) (p<0.05), thus suggesting that an alteration of the cascade responsible for ROS production may be implicated in the complex etipathogenesis of COF.