Patterning the vertebrate heart

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various mo...

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Bibliographic Details
Published inNature reviews. Genetics Vol. 3; no. 7; pp. 544 - 556
Main Author Harvey, Richard P.
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.07.2002
Subjects
Animals
Body Patterning - physiology
Coronary vessels
Embryonic and Fetal Development - physiology
Embryos
Functional Laterality
Heart
Heart - embryology
Humans
Lungs
Morphogenesis
Pulmonary arteries
Stem Cells - physiology
Veins & arteries
Vertebrates
Vertebrates - embryology
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Summary:The mammalian heart is crafted from a few progenitor cells that are subject to rapidly changing sets of instructions from their environment and from within. These instructions cause them to migrate, expand and diversify in lineage, and acquire form and function. Molecular information from various model systems, combined with increasingly detailed morphogenetic data, has provided insights into some of these key events. Many congenital heart abnormalities might arise from defects in the early stages of heart development, therefore it is important to understand the molecular pathways that underlie the lineage specification and patterning processes that shape this organ.
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ISSN:1471-0056
1471-0064
DOI:10.1038/nrg843