The ventral hippocampal regulation of prepulse inhibition and its disruption by apomorphine in rats are not mediated via the fornix

• Published in: Neuroscience Vol. 123; no. 3; pp. 675 - 685
• Main Authors: Swerdlow, N.R, Shoemaker, J.M, Noh, H.R, Ma, L, Gaudet, I, Munson, M, Crain, S, Auerbach, P.P
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 2004; Elsevier
• Subjects: Adult and adolescent clinical studies; Animals; apomorphine; Apomorphine - pharmacology; Biological and medical sciences; dopamine; Fornix, Brain - drug effects; Fornix, Brain - physiology; Fundamental and applied biological sciences. Psychology; hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Medical sciences; Neural Inhibition - drug effects; Neural Inhibition - physiology; prepulse inhibition; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Rats; Rats, Sprague-Dawley; Reflex, Startle - drug effects; Reflex, Startle - physiology; Schizophrenia; startle; Vertebrates: nervous system and sense organs; hippocampus; PPI; prepulse inhibition; schizophrenia; startle; NAC; FX; VH; apomorphine; ANOVA; NMDA; dopamine; DA; Agonist; Dopamine; Rat; Dopamine receptor; Rodentia; Central nervous system; Schizophrenia; Catecholamine; Encephalon; Psychosis; Vertebrata; Mammalia; Animal; Dopamine agonist; Neurotransmitter; Hippocampus
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2003.08.028

Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is impaired in schizophrenia. We have reported that PPI is regulated by the ventral hippocampus (VH) and that the PPI disruptive effects of the dopamine agonist apomorphine are enhanced 4 weeks after excitotoxic lesions of the VH. The mechanisms responsible for the VH influence on PPI are not understood, but have been ascribed to interactions between the VH and nucleus accumbens. In the present study, we examined whether the VH influence on PPI and its dopaminergic regulation is dependent on the integrity of the VH-accumbens projection via the fornix. First, the PPI-disruptive effects of intra-VH NMDA infusion were assessed after sham or electrolytic transection of the fornix. Second, the PPI-disruptive effects of apomorphine were assessed 1 month after excitotoxic or electrolytic lesions of the VH, or after fornix transection. Intra-VH N-methyl- d-aspartate infusion significantly disrupted PPI; this effect was unaffected by fornix lesions. The PPI-disruptive effects of apomorphine were significantly enhanced by excitotoxic or electrolytic lesions of the VH, but not by fornix transection. The influence of the VH on PPI and its dopaminergic regulation does not appear to be mediated via the fornix. The enhanced sensitivity to the PPI-disruptive effects of apomorphine after VH lesions is not dependent on excitotoxin-induced changes in the VH or its downstream projections.