Dendritic cell migration to lymph nodes: cytokines, chemokines, and lipid mediators

Mobilization of dendritic cells into lymphatic vessels requires cytokine stimulation and induction of the chemokine receptor CCR7. The respective roles of the CCR7 ligands CCL19 and CCL21 in mediating migration are not fully defined, but chemotaxis to CCL19 mediates Langerhans cell exit from the epi...

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Bibliographic Details
Published inSeminars in immunology Vol. 13; no. 5; pp. 267 - 274
Main Author Randolph, Gwendalyn J
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2001
Subjects
Adjuvants, Immunologic - physiology
Animals
CCL19 protein
CCL21 protein
CCR7 protein
Cell Movement - immunology
Chemokines - physiology
Cytokines - physiology
dendritic cell migration / lymph nodes / cytokines / chemokines / lipid mediators
Dendritic Cells - cytology
Humans
Lipids - physiology
Lymph Nodes - cytology
Lymph Nodes - immunology
dendritic cell migration / lymph nodes / cytokines / chemokines / lipid mediators
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Summary:Mobilization of dendritic cells into lymphatic vessels requires cytokine stimulation and induction of the chemokine receptor CCR7. The respective roles of the CCR7 ligands CCL19 and CCL21 in mediating migration are not fully defined, but chemotaxis to CCL19 mediates Langerhans cell exit from the epidermis. Optimal chemotaxis to CCL19 occurs when DCs are triggered with exogenous leukotriene C4, an eicosanoid transported out of the cell via the ATP binding cassette (ABC) transporter multidrug resistance related protein 1 (MRP1, ABCC1). Indeed, MRP1 and the related multidrug resistance protein 1 (MDR1, p-glycoprotein, ABCB1) may control the intracellular and extracellular accumulation of key signaling lipids that regulate dendritic cell migration.
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ISSN:1044-5323
1096-3618
DOI:10.1006/smim.2001.0322