Vaccinia virus morphogenesis and dissemination

Vaccinia virus is the smallpox vaccine. It is the most intensively studied poxvirus, and its study has provided important insights about virus replication in general and the interactions of viruses with the host cell and immune system. Here, the entry, morphogenesis and dissemination of vaccinia vir...

Full description

Saved in:
Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 16; no. 10; pp. 472 - 479
Main Authors Roberts, Kim L, Smith, Geoffrey L
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2008
Subjects
Animals
Gene Expression Regulation, Viral
Humans
Internal Medicine
Poxvirus
Vaccinia - transmission
Vaccinia - virology
Vaccinia virus
Vaccinia virus - genetics
Vaccinia virus - physiology
Viral Proteins - genetics
Viral Proteins - metabolism
Virus Internalization
Virus Replication
Online AccessGet full text

Cover

More Information
Summary:Vaccinia virus is the smallpox vaccine. It is the most intensively studied poxvirus, and its study has provided important insights about virus replication in general and the interactions of viruses with the host cell and immune system. Here, the entry, morphogenesis and dissemination of vaccinia virus are considered. These processes are complicated by the existence of two infectious vaccinia virus particles, called intracellular mature virus (IMV) and extracellular enveloped virus (EEV). The IMV particle is surrounded by one membrane, and the EEV particle comprises an IMV particle enclosed within a second lipid membrane containing several viral antigens. Consequently, these virions have different biological properties and play different roles in the virus life cycle.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2008.07.009