The front line of research into immunoglobin G4-related disease - Do autoantibodies cause immunoglobin G4-related disease?

IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Although IgG4-RD is attracting strong attention as a new clinical entity, the pathogenesis of IgG4-RD and the rol...

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Published inModern rheumatology Vol. 29; no. 2; pp. 214 - 218
Main Authors Umehara, Hisanori, Okazaki, Kazuichi, Kawano, Mitsuhiro, Tanaka, Yoshiya
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 04.03.2019
Subjects
acquired immunity
autoantibody
autoantigen
Autoantigens - immunology
autoimmunity
Humans
IgG4-RD
Immunoglobulin G - immunology
Immunoglobulin G4-Related Disease - immunology
innate immunity
pathogenesis
pathogenesis
autoantibody
autoimmunity
innate immunity
acquired immunity
autoantigen
IgG4-RD
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Summary:IgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. Although IgG4-RD is attracting strong attention as a new clinical entity, the pathogenesis of IgG4-RD and the roles of IgG4 are still unknown. Recently, self-antigens including Laminin 511 E8, Galectin-3 and Annexin A11, have been reported from one to the next as autoantigens which may be involved in the pathogenesis of IgG4-RD. In this review, we describe up-to-date information on the research of this emerging disease entity. Moreover, we discuss the pathogenesis of IgG4-RD by focusing on recent reports concerning autoantibodies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1439-7595
1439-7609
DOI:10.1080/14397595.2018.1558519