Insulin receptors and glucose uptake in the human parasite Schistosoma mansoni

• Published in: Parasite (Paris) Vol. 15; no. 4; pp. 573 - 579
• Main Authors: Ahier, A., Khayath, N., Vicogne, J., Dissous, C.
• Format: Journal Article
• Language: English
• Published: Paris EDP Sciences 01.12.2008; Princeps
• Subjects: Adenosine Triphosphate - metabolism; Amino Acid Sequence; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Biochemistry. Physiology. Immunology. Molecular biology; Biological and medical sciences; Biomphalaria - parasitology; Cricetinae; Fundamental and applied biological sciences. Psychology; glucose; Glucose - metabolism; Host-Parasite Interactions - physiology; Humans; inhibiteur; inhibitor; Insulin - blood; Insulin - metabolism; insulin receptor; insuline; Invertebrates; Medical sciences; Mesocricetus; Nemathelminthia. Plathelmintha; Pharmacology. Drug treatments; Physiology. Development; Protein-Tyrosine Kinases - metabolism; Receptor, Insulin - chemistry; Receptor, Insulin - classification; Receptor, Insulin - metabolism; RNA Interference; récepteur; Schistosoma mansoni; Schistosoma mansoni - metabolism; Schistosomiasis mansoni - metabolism; Schistosomiasis mansoni - parasitology; Sequence Alignment; tyrosine kinase; Human; Tyrosine; Schistosoma mansoni; Anthelmintic; Enzyme; Transferases; Plathelmintha; Parasite; Glucose; Trematoda; Uptake; Kinase; Pathogenic; Helmintha; Inhibitor; Invertebrata; Insulin receptor
• ISSN: 1252-607X; 1776-1042
• DOI: 10.1051/parasite/2008154573

Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed. Très peu de choses sont connues concernant la signalisation insuline chez le schistosome malgré son importance potentielle dans le dialogue hôte-parasite ainsi que dans la croissance et le développement du parasite. La caractérisation récente de deux récepteurs à l’insuline chez Schistosoma mansoni (SmIR-1 and SmIR-2) nous a conduit à reconsidérer la question de l’importance potentielle de l’insuline dans les interactions hôte-schistosome. Dans ce travail, nous avons démontré que l’insuline peut réguler la prise de glucose chez le schistosome et nous avons évalué l’implication de SmIR-1 et de SmIR-2 dans ce processus. La possibilité de développer des inhibiteurs spécifiques de l’activité tyrosine kinase de SmIR-1 et SmIR-2 pour cibler le schistosome est discutée.