Exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin and tetraethyl lead affects lung mitochondria bioenergetics

• Published in: Toxicology mechanisms and methods Vol. 20; no. 1; pp. 1 - 6
• Main Authors: Simões, Anabela Marques, Duarte, Filipe Valente, Teodoro, João Soeiro, Rolo, Anabela Pinto, Palmeira, Carlos Marques
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2010; Taylor & Francis
• Subjects: Adenosine Triphosphatases - metabolism; Adenosinetriphosphatase; Animals; Bioenergetics; Data processing; Dioxin; Dioxins; Energy Metabolism - drug effects; Environmental pollutants; Environmental Pollutants - toxicity; In Vitro Techniques; Lead; Lung; Lung - drug effects; Lung - metabolism; Lung diseases; Membrane Potential, Mitochondrial - drug effects; Membrane Potential, Mitochondrial - physiology; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondria - physiology; Mitochondrial Membrane Transport Proteins - drug effects; Mitochondrial Membrane Transport Proteins - physiology; Mitochondrial Swelling - drug effects; Mitochondrial Swelling - physiology; Oxidative phosphorylation; Oxidative Phosphorylation - drug effects; Oxygen Consumption - drug effects; Pollutants; Polychlorinated Dibenzodioxins - toxicity; Respiration; Swine; TCDD; Tetraethyl Lead - toxicity; Toxicity

Environmental pollutants such as TCDD and tetraethyl lead are extremely toxic and related with pulmonary disease development. Lung mitochondria are primary cellular targets for dioxins exposure-induced toxicity. TCDD showed a delay in the repolarization after a phosphorylative cycle and a decrease o...