Prognostic implications of estrogen receptor 1 and vascular endothelial growth factor A expression in primary gallbladder carcinoma

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 4; pp. 1243 - 1250
• Main Authors: Zhang, Ling-Qiang, Xu, Xin-Sen, Wan, Yong, Song, Si-Dong, Wang, Rui-Tao, Chen, Wei, Wang, Zhi-Xin, Chang, Hu-Lin, Wei, Ji-Chao, Dong, Ya-Feng, Liu, Chang
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.01.2015
• Subjects: 1;Vascular; Biomarkers, Tumor - analysis; Carcinoma - chemistry; Carcinoma - mortality; Carcinoma - secondary; Carcinoma - surgery; carcinoma;Estrogen; Chi-Square Distribution; Estrogen Receptor alpha - analysis; Female; Gallbladder; Gallbladder Neoplasms - chemistry; Gallbladder Neoplasms - mortality; Gallbladder Neoplasms - pathology; Gallbladder Neoplasms - surgery; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Multivariate Analysis; Neoplasm Staging; Proportional Hazards Models; receptor; Retrospective Studies; Retrospective Study; Risk Factors; Time Factors; Treatment Outcome; Up-Regulation; Vascular Endothelial Growth Factor A - analysis; Vascular endothelial growth factor A; Estrogen receptor 1; Gallbladder carcinoma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v21.i4.1243

AIM: To investigate the prognostic significance of estrogen receptor 1(ER1) and vascular endothelial growth factor A(VEGF-A) expression in primary gallbladder carcinoma(GBC) to identify new prognostic markers for this malignancy.METHODS: Using immunohistochemistry, we investigated ER1 and VEGF-A expression in 78 GBC and 78 cholelithiasis(CS) tissues. The results were correlated with clinicopathological features. Univariate and multivariate analyses were performed to evaluate the relationship between ER1 and VEGF-A expression and patients’ prognosis. Further Kaplan-Meier survival analysis was also performed. RESULTS: ER1 and VEGF-A expression was significantly higher in GBC compared with CS(47/78 vs 28/78, P < 0.05; 51/78 vs 33/78, P < 0.05). ER1 expression was correlated with gender(P < 0.05) and VEGF-A expression was correlated with tumor differentiation in GBC patients(P < 0.05). In univariate analysis, age and tumor node metastasis(TNM) stage were factors associated with GBC prognosis(P < 0.05). Although there was no statistical difference between the expression of ER1 or VEGF-A and overall survival, the high expression of ER1 combined with VEGF-A predicted a poor prognosis for GBC patients(16.30 ± 1.87 vs 24.97 ± 2.09, log-rank P < 0.05). In multivariate analysis, combined expression of ER1 and VEGF-A and TNM stage were independent prognostic factors for GBC patients(P < 0.05).CONCLUSION: Combined expression of ER1 and VEGF-A is a potential prognostic marker for GBC patients. Clinical detection of ER1 and VEGF-A in surgically resected GBC tissues would provide animportant reference for decision-making of postoperative treatment programs.