Purmorphamine activates the Hedgehog pathway by targeting Smoothened

Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstr...

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Bibliographic Details
Published inNature chemical biology Vol. 2; no. 1; pp. 29 - 30
Main Authors Chen, James K, Sinha, Surajit
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.01.2006
Subjects
Animals
Cell Membrane - metabolism
Cell Proliferation - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Hedgehog Proteins
Mice
Morpholines - pharmacology
NIH 3T3 Cells
Osteoblasts - drug effects
Osteoblasts - metabolism
Purines - pharmacology
Receptors, G-Protein-Coupled - metabolism
Signal Transduction - drug effects
Signal Transduction - physiology
Smoothened Receptor
Stem cells
Stem Cells - drug effects
Stem Cells - metabolism
Tissue Engineering
Trans-Activators - metabolism
Veratrum Alkaloids - pharmacology
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Summary:Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1552-4450
1552-4469
DOI:10.1038/nchembio753