Synthetic strategies and biomedical applications of I-III-VI ternary quantum dots
Surface modified and bioconjugated quantum dots (QDs) are of central importance in biomedical applications. In this regard, particularly I-III-VI QDs are of specific interest for biosensors, multimodal imaging, chemotherapy and for phototherapy in theranostic applications. Surface modification allow...
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| Published in | Journal of materials chemistry. B, Materials for biology and medicine Vol. 5; no. 31; pp. 6193 - 6216 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
21.08.2017
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| Online Access | Get full text |
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| Summary: | Surface modified and bioconjugated quantum dots (QDs) are of central importance in biomedical applications. In this regard, particularly I-III-VI QDs are of specific interest for biosensors, multimodal imaging, chemotherapy and for phototherapy in theranostic applications. Surface modification allows management of the physico-chemical properties, biocompatibility, and pharmacological properties. This review is anticipated to provide an introduction to new researchers about I-III-VI type QDs relating to their synthesis, optical properties, surface modification, bioconjugation, and their applications in biosensors, biological imaging, drug delivery, photothermal therapy and photodynamic therapy. We also highlight introducing magnetic metals and nanoparticles to these QDs for multimodal imaging applications and have addressed toxicity related issues. Finally, we summarize the results obtained and give a short outlook on future directions of I-III-VI based QDs for biomedical applications.
In this review, we discuss recent advances of I-III-VI QDs with a major focus on synthesis and biomedical applications; advantages include low toxicity and fluorescent tuning in the biological window. |
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| Bibliography: | Mulu Alemayehu Abate received his master's degree in Inorganic Chemistry from Arba-Minch University, Ethiopia in 2013. Currently, he is a PhD candidate under the supervision of Prof. Jia-Yaw Chang at National Taiwan University of Science and Technology department of Chemical Engineering, Taiwan. His recent research mainly focuses on quantum dot sensitized solar cells. Adi Permadi received his BSc degree in Chemical Engineering from Gadjah Mada University, Indonesia in 2007 and his MEng degree in Chemical Engineering from Bandung Institute of Technology, Indonesia in 2010. Currently he is a PhD candidate in the Departments of Chemical Engineering, National Taiwan University of Science and Technology, Taiwan. His research focus, under the supervision of Prof. Jia-Yaw Chang, is on ternary quantum dots for staining cancer cells. Wubshet Mekonnen Girma received his BSc degree in Applied Chemistry, from University of Gondar, Ethiopia in 2010 and his MSc degree in Inorganic Chemistry from Addis Ababa University, Ethiopia in 2013. Currently he is a PhD candidate in the Departments of Chemical Engineering, National Taiwan university of Science and Technology. His research fields focus on ternary copper based nanomaterials for theranostic application under the supervision of Prof. Jia-Yaw Chang. Jia-Yaw Chang received his PhD in Chemistry from National Tsing Hua University in 2004 under the supervision of Prof. Yong-Chien Ling. He was a visiting researcher in the laboratory of Prof. Weihong Tan at the University of Florida in 2003. From 2004 to 2009, he was a research scientist and a project leader at Industrial Technology Research Institute. He joined National Taiwan University of Science and Technology in 2009 as an Assistant Professor and became a Professor in 2015. His research interests include the synthesis and functionalization of nanomaterials in the areas of energy conversion, drug delivery, light-activated therapy, and bioimaging applications. Mochamad Zakki Fahmi received his PhD at Chemical Engineering, National Taiwan University of Science and Technology in 2014 under the supervision of Prof. Jia-Yaw Chang. Currently, he is Assistant Professor at Department of Chemistry, Universitas Airlangga, Indonesia. His research interests were focused on developing synthesis and modification of polymers and nanomaterials for bioapplication. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2050-750X 2050-7518 |
| DOI: | 10.1039/c7tb01156c |