Short-term potentiation of ventilation after different levels of hypoxia
Constance S. Kaufman Pulmonary Research Laboratory, Departments of 1 Pediatrics and 2 Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112 Short-term potentiation of ventilation (VSTP) may be observed in healthy subjects on sudden termination of an hypoxic stimulus. We hy...
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Published in | Journal of applied physiology (1985) Vol. 86; no. 5; pp. 1478 - 1482 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Bethesda, MD
Am Physiological Soc
01.05.1999
American Physiological Society |
Subjects | |
Online Access | Get full text |
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Summary: | Constance S. Kaufman Pulmonary Research Laboratory, Departments of
1 Pediatrics and
2 Physiology, Tulane University
School of Medicine, New Orleans, Louisiana 70112
Short-term
potentiation of ventilation (VSTP) may be observed in healthy subjects
on sudden termination of an hypoxic stimulus. We hypothesized that the
level of hypoxia preceding normoxia would modify the duration and
magnitude of the ensuing ventilatory decay. Ten healthy adults were
studied on two different occasions, during which they were randomly
exposed to isocapnic 6 or 10% O 2
for 60 s and then switched to an isocapnic normoxic gas mixture. Both hypoxic gases induced significant ventilatory responses, and mean peak
minute ventilation before the isocapnic normoxic switch was higher in
6% O 2
( P < 0.001). The fast time constant
of the two-exponential equation representing the best fit for
ventilatory decay was unaffected by the magnitude of the hypoxic
stimulus. However, the slow time constant, which is considered to
represent VSTP, was markedly prolonged in 6% compared with 10%
O 2 [106.7 ± 11.3 vs.
38.2 ± 6.1 (SD) s, respectively; P < 0.0001]. This result indicates that VSTP is
stimulus dependent. We conclude that the magnitude of hypoxia preceding
a normoxic transient modifies VSTP characteristics. We speculate that
the interdependence function of ventilatory stimulus and short-term
potentiation is crucial for preservation of system stability during
transitions from high to low ventilatory drives.
respiratory afterdischarge; isocapnia; normoxia; afterdischarge |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 8750-7587 1522-1601 |
DOI: | 10.1152/jappl.1999.86.5.1478 |