Neurobiology of bruxism: The impact of stress (Review)

• Published in: Biomedical reports Vol. 20; no. 4; p. 59
• Main Authors: Pavlou, Ioannis A, Spandidos, Demetrios A, Zoumpourlis, Vassilis, Papakosta, Veronica K
• Format: Journal Article
• Language: English
• Published: England Spandidos Publications 01.04.2024; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Brain; Bruxism; Central nervous system; Corticosterone; Degeneration; Dental disorders; Dopamine; Etiology; Hypothalamic-pituitary-adrenal axis; Hypothalamus; Mediation; Muscle function; Muscles; Nervous system; Neurons; Neurophysiology; Neurosciences; Pathogenesis; Physiology; Pituitary; Review; Serotonin; Smooth muscle; neurodegeneration; HPA axis; chronic stress; hippocampus
• ISSN: 2049-9434; 2049-9442
• DOI: 10.3892/br.2024.1747

Bruxism is a non-functional involuntary muscle activity that affects more than one-third of the population at some point in their lives. A number of factors have been found to be related to the etiopathogenesis of bruxism; therefore, the condition is considered multifactorial. The most commonly accepted factor is stress. Stress has long been considered to increase muscle tone and to reduce the pain threshold. Current evidence indicates that exposure to chronic stress, distress and allostatic load ignite neurological degeneration and the attenuation of critical neuronal pathways that are highly implicated in the orofacial involuntary muscle activity. The present review discusses the negative effects that chronic stress exerts on certain parts of the central nervous system and the mechanisms through which these changes are involved in the etiopathogenesis of bruxism. The extent of these morphological and functional changes on nerves and neuronal tracts provides valuable insight into the obstacles that need to be overcome in order to achieve successful treatment. Additionally, particular emphasis is given on the effects of bruxism on the central nervous system, particularly the activation of the hypothalamic-pituitary-adrenal axis, as this subsequently induces an increase in circulating corticosterone levels, also evidenced by increased levels of salivary cortisol, thereby transforming bruxism into a self-reinforcing loop.