iPSC lines that do not silence the expression of the ectopic reprogramming factors may display enhanced propensity to genomic instability
Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and...
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Published in | Cell research Vol. 20; no. 10; pp. 1092 - 1095 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.10.2010
Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | Here, we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells (iPSCs) may predispose iPSCs to genomic instability. We encourage stem cell scientists to undertake an extensive characterization and standardization of much larger cohorts of iPSC lines in order to set up rigorous criteria to define safe and stable bonafide iPSCs. |
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Bibliography: | iPSCs 31-1568/Q Q987 Q26 genomic stability gene silencing reprogramming factors iPSCs; genomic stability; reprogramming factors; gene silencing ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1001-0602 1748-7838 |
DOI: | 10.1038/cr.2010.125 |