Carbapenemase-producing Enterobacteriaceae in South Korea: a report from the National Laboratory Surveillance System

• Published in: Future microbiology Vol. 13; no. 7; pp. 771 - 783
• Main Authors: Yoon, Eun-Jeong, Yang, Ji Woo, Kim, Jung Ok, Lee, Hyukmin, Lee, Kwang Jun, Jeong, Seok Hoon
• Format: Journal Article
• Language: English
• Published: England Future Medicine Ltd 01.06.2018
• Subjects: Anti-Bacterial Agents - pharmacology; Antibiotics; carbapenem-nonsusceptible Enterobacteriaceae; Carbapenem-Resistant Enterobacteriaceae - classification; Carbapenem-Resistant Enterobacteriaceae - drug effects; Carbapenem-Resistant Enterobacteriaceae - genetics; Carbapenem-Resistant Enterobacteriaceae - isolation & purification; Carbapenemase; carbapenemase-producing Enterobacteriaceae; Carbapenems - pharmacology; Disease prevention; E coli; Enterobacteriaceae; Enterobacteriaceae Infections - epidemiology; Enterobacteriaceae Infections - microbiology; Epidemics; Epidemiology; Genes; Humans; Laboratories; Laboratories - statistics & numerical data; Microbial Sensitivity Tests; Multilocus Sequence Typing; national surveillance study; Population density; Republic of Korea - epidemiology; Surveillance; Republic of Korea; United States > US; South Korea; national surveillance study; carbapenem-nonsusceptible Enterobacteriaceae; carbapenemase-producing Enterobacteriaceae
• ISSN: 1746-0913; 1746-0921
• DOI: 10.2217/fmb-2018-0022

To assess the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in South Korea. From 2011 to 2015, 2487 carbapenem-nonsusceptible Enterobacteriaceae were collected through the Korean National Laboratory Surveillance System. Disk-diffusion for antimicrobial susceptibility, PCR/sequencing to detect carbapenemase genes and multilocus sequence typing for molecular epidemiology were carried out. The number of carbapenem-nonsusceptible Enterobacteriaceae was increasing approximately 1.5-fold per year and the proportion of CPEs was exponentially confirmed from 2014. KPC was the most dominant, mostly associated with ST11 and ST307, NDM was the second and OXA-48-like was the third dominant carbapenemases. The IMP, VIM and GES-5 CPEs were identified sporadically. The nation-wide spreads of KPC, NDM and OXA-48-like CPEs were in an alarming epidemiological stage.