Janus kinases: dermatological perspective, a review

Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway. This pathway is triggered by cytokines participating in the inflammatory process, innate and adaptive i...

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Bibliographic Details
Published inJournal of the Egyptian Women’s Dermatologic Society Vol. 17; no. 2; pp. 67 - 70
Main Authors Nada, Hanan, Elmasry, Maha, El Sharkawy, Dina, Mamdouh, Sally
Format Journal Article
LanguageEnglish
Published Wolters Kluwer India Pvt. Ltd 01.05.2020
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Subjects
alopecia areata
anti-inflammatory
Atopic dermatitis
Development and progression
janus kinase
Mutual fund industry
Psoriasis
signal transducer and activator of transcription
Tofacitinib
Tyrosine
vitiligo
psoriasis
anti-inflammatory
vitiligo
atopic dermatitis
Janus kinase
alopecia areata
signal transducer and activator of transcription
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Summary:Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway. This pathway is triggered by cytokines participating in the inflammatory process, innate and adaptive immunological responses, as well as cell growth. Current researches suggest the possible disruption in JAK/signal transducer and activator of transcription pathway in different autoimmune and inflammatory skin diseases, such as psoriasis, vitiligo, atopic dermatitis, and alopecia areata. Various drugs that activate or block this pathway are under study for the assessment of their possible role in skin diseases.
ISSN:1687-1537
2090-2565
2090-2565
DOI:10.4103/JEWD.JEWD_2_20