Blood transfusion and immunomodulation: a possible mechanism

To induce an immunogenic response in vivo, an antigen-presenting (stimulator) cell must present both antigen-specific (class II MHC) and an accessory signal to the CD4 T cell. Failure to express the accessory signal has been shown in vitro to induce a state of specific unresponsiveness (anergy) in t...

Full description

Saved in:
Bibliographic Details
Published inVox sanguinis Vol. 65; no. 1; p. 18
Main Authors Mincheff, M S, Meryman, H T, Kapoor, V, Alsop, P, Wötzel, M
Format Journal Article
LanguageEnglish
Published England 01.01.1993
Subjects
Antibodies, Monoclonal
Blood Preservation - methods
Gamma Rays
Histocompatibility Antigens Class II - blood
Humans
Neutrophils - immunology
Neutrophils - radiation effects
Signal Transduction - immunology
Transfusion Reaction
Ultraviolet Rays
Online AccessGet more information

Cover

More Information
Summary:To induce an immunogenic response in vivo, an antigen-presenting (stimulator) cell must present both antigen-specific (class II MHC) and an accessory signal to the CD4 T cell. Failure to express the accessory signal has been shown in vitro to induce a state of specific unresponsiveness (anergy) in the T cell. We have shown that although stimulator cells in blood continue to express class II MHC molecules during refrigerated storage, their ability to present the accessory signal diminishes, reaching zero in all units tested by about 13 days. This implies that blood in excess of 2 weeks old should not alloimmunize but could induce some degree of immunosuppression. UV-B irradiation and, to a lesser extent, gamma-irradiation, were also shown to inhibit expression of the accessory signal by stimulator cells in blood.
ISSN:0042-9007
DOI:10.1111/j.1423-0410.1993.tb04519.x