The effect of the antihistamine cimetidine on ultraviolet-radiation-induced tumorigenesis in the hairless mouse

This experiment investigated the effect on ultraviolet (UV) radiation-induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the en...

Full description

Saved in:
Bibliographic Details
Published inPhotochemistry and photobiology Vol. 53; no. 5; p. 639
Main Authors Matheson, M J, Reeve, V E
Format Journal Article
LanguageEnglish
Published United States 01.05.1991
Subjects
Animals
Antineoplastic Agents
Cimetidine - therapeutic use
Female
Mice
Mice, Hairless
Neoplasms, Radiation-Induced - prevention & control
Skin Neoplasms - etiology
Skin Neoplasms - prevention & control
Time Factors
Ultraviolet Rays
Online AccessGet more information

Cover

More Information
Summary:This experiment investigated the effect on ultraviolet (UV) radiation-induced tumorigenesis of feeding the histamine type 2 receptor antagonist, cimetidine, to Skh:HR mice. Cimetidine was fed to one group during a 70 day period of chronic UVR (5 days/week for 10 weeks), to a second group from the end of this period to the end of the experiment at 286 days and a third group was fed a control diet only throughout the experiment. Feeding mice cimetidine during the 70 day period of irradiation protected them against the later development of skin tumours.
ISSN:0031-8655
DOI:10.1111/j.1751-1097.1991.tb08491.x