Release of glutamate from striatum of freely moving rats by pros-methylimidazoleacetic acid

The effect of pros-methylimidazoleacetic acid (p-MIAA) was measured on the release of glutamate and aspartate from cerebral cortex, hippocampus, and striatum of freely moving rats, and on the uptake of 14C by striatal slices incubated in the presence of L-[14C]-glutamate. Twenty-four hours after imp...

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Bibliographic Details
Published inJournal of neurochemistry Vol. 64; no. 2; p. 788
Main Authors Blandina, P, Cherici, G, Moroni, F, Prell, G D, Green, J P
Format Journal Article
LanguageEnglish
Published England 01.02.1995
Subjects
Animals
Aspartic Acid - metabolism
Carbon - pharmacokinetics
Carbon Radioisotopes
Corpus Striatum - metabolism
Glutamic Acid - metabolism
Imidazoles - pharmacology
In Vitro Techniques
Male
Motor Activity
Rats
Rats, Wistar
Veratridine - pharmacology
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Summary:The effect of pros-methylimidazoleacetic acid (p-MIAA) was measured on the release of glutamate and aspartate from cerebral cortex, hippocampus, and striatum of freely moving rats, and on the uptake of 14C by striatal slices incubated in the presence of L-[14C]-glutamate. Twenty-four hours after implantation of a dialysis fiber, striatum, hippocampus, or cerebral cortex spontaneously released both glutamate and aspartate in the micromolar range. p-MIAA (1 microM to 1 mM), added to the dialysis perfusate, elicited a concentration-dependent increase of glutamate release from striatum with a maximal increase of about threefold. This effect did not occur in hippocampus or cortex. In none of these regions did p-MIAA increase aspartate release significantly. The p-MIAA effect was not mimicked by its isomer tele-methyl-imidazoleacetic acid. p-MIAA did not influence the uptake of glutamate by striatal slices. The glutamate-releasing action of p-MIAA may affect striatal function and explain the positive correlation between levels of p-MIAA in CSF and the severity of Parkinson's disease.
ISSN:0022-3042
DOI:10.1046/j.1471-4159.1995.64020788.x