Late-type allergy to the X-ray contrast medium Solutrast® (iopamidol)

• Published in: Contact dermatitis Vol. 40; no. 5; pp. 248 - 250
• Main Authors: Gall, Helmut, Pillekamp, Hans, Peter, Ralf-Uwe
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1999; Blackwell
• Subjects: adverse drug reactions; Allergens - adverse effects; Biological and medical sciences; Contrast Media - adverse effects; Contrast Media - chemistry; cross-reactivity; Drug toxicity and drugs side effects treatment; Facial Dermatoses - chemically induced; Humans; Hypersensitivity, Delayed - chemically induced; Iopamidol - adverse effects; Iopamidol - chemistry; late-type allergy; maculopapular rashes; Male; Medical sciences; Middle Aged; Miscellaneous (drug allergy, mutagens, teratogens...); non-ionic X-ray contrast media; Patch Tests; Pharmacology. Drug treatments; Solutrast® (iopamidol); Case study; Human; Immunopathology; Allergy; Skin disease; Late; Delayed toxicity; Iopamidol; Erythema; Iodine Organic compounds; Contrast media
• ISSN: 0105-1873; 1600-0536
• DOI: 10.1111/j.1600-0536.1999.tb06058.x

In the past few years, there have been an increasing number of publications on delayed intolerance reactions, including rashes, following the use of X‐ray contrast media. We report a patient in whom infiltrated erythema of the face and generalized maculopapular rashes occurred on 2 occasions, within 1 day, following the use of the X‐ray contrast medium Solutrast® (iopamidol) for coronary angiography. The allergological investigations for clarification included prick tests and patch tests using a series of contrast media, as well as individual intravenous provocation tests. We found the cause to be a late‐type allergy to the active substance iopamidol contained in the contrast medium Solutrast®. We found a concomitant cross‐reactivity to the contrast media iopromid and iomeprol. All 3 contrast media represent the monomeric, non‐ionic type.