Rearrangement of TCR gamma chain gene involving JP1 suggests early thymocyte origin of peripheral T-cell lymphoma

• Published in: European journal of haematology Vol. 42; no. 4; p. 368
• Main Authors: Leber, B F, Amlot, P, Hoffbrand, A V, Norton, J D
• Format: Journal Article
• Language: English
• Published: England 01.04.1989
• Subjects: Antigens, Surface - analysis; DNA - genetics; DNA Probes; DNA Restriction Enzymes; Humans; Immunoglobulin Heavy Chains - genetics; Lymphoma - genetics; Lymphoma - immunology; Lymphoma - pathology; Nucleic Acid Hybridization; Phenotype; Receptors, Antigen, T-Cell - genetics; RNA - genetics; T-Lymphocytes - immunology; Thymus Gland - pathology

Peripheral T-cell lymphomas (PTL) are morphologically and immunophenotypically heterogeneous. We have examined a series of cases to determine whether this heterogeneity is reflected at the level of developmentally specific T-cell receptor (TCR) gene rearrangement. 4 of 5 cases had clonal rearrangeme...