Rearrangement of TCR gamma chain gene involving JP1 suggests early thymocyte origin of peripheral T-cell lymphoma

Peripheral T-cell lymphomas (PTL) are morphologically and immunophenotypically heterogeneous. We have examined a series of cases to determine whether this heterogeneity is reflected at the level of developmentally specific T-cell receptor (TCR) gene rearrangement. 4 of 5 cases had clonal rearrangeme...

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Bibliographic Details
Published inEuropean journal of haematology Vol. 42; no. 4; p. 368
Main Authors Leber, B F, Amlot, P, Hoffbrand, A V, Norton, J D
Format Journal Article
LanguageEnglish
Published England 01.04.1989
Subjects
Antigens, Surface - analysis
DNA - genetics
DNA Probes
DNA Restriction Enzymes
Humans
Immunoglobulin Heavy Chains - genetics
Lymphoma - genetics
Lymphoma - immunology
Lymphoma - pathology
Nucleic Acid Hybridization
Phenotype
Receptors, Antigen, T-Cell - genetics
RNA - genetics
T-Lymphocytes - immunology
Thymus Gland - pathology
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Summary:Peripheral T-cell lymphomas (PTL) are morphologically and immunophenotypically heterogeneous. We have examined a series of cases to determine whether this heterogeneity is reflected at the level of developmentally specific T-cell receptor (TCR) gene rearrangement. 4 of 5 cases had clonal rearrangements of TCR beta and gamma chain genes; one of these also had a probable DQ52-J immunoglobulin heavy chain gene rearrangement. 2 of the 4 TCR gamma gene rearrangements involved the most 5' J region, JP1, a characteristic of immature thymocytes. These 2 cases also had immunophenotypic features of immaturity. Taken together, our results suggest that TCR gene rearrangement is correlated with surface marker data and shows that in some cases PTL may arise from a very early stage of thymocyte maturation.
ISSN:0902-4441
DOI:10.1111/j.1600-0609.1989.tb01227.x