Preparation, characterization and degradation characteristics of polyanhydrides containing poly(ethylene glycol)

• Published in: Polymer international Vol. 48; no. 1; pp. 47 - 52
• Main Authors: Jiang, H L, Zhu, K J
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.01.1999; Wiley
• Subjects: Applied sciences; biodegradable polymer; Biodegradation; Carboxylic acids; Chemical modification; Copolymerization; Crystal structure; Exact sciences and technology; Infrared spectroscopy; modified polyanhydride; Molecular structure; Monomers; Organic polymers; Physicochemistry of polymers; Polyethylene glycols; Polymers with particular properties; Preparation, kinetics, thermodynamics, mechanism and catalysts; protein pulsed release; Terpolymer; Molecular structure; Controlled release form; Control release polymer; Chemical stability; Drug carrier; Condensation polymerization; Chemical degradation; Ethylene oxide copolymer; Experimental study; Hydrolysis; Sebacic acid; Anhydride copolymer; Preparation; Imide copolymer; Property structure relationship; Block copolymer
• ISSN: 0959-8103; 1097-0126
• DOI: 10.1002/(SICI)1097-0126(199901)48:1<47::AID-PI107>3.0.CO;2-X

Poly(ethylene glycol) (PEG) segments were introduced into a polyanhydride main chain by copolymerization of terminal‐carboxylated poly(ethylene glycol) with diacidic monomers (sebacic acid and trimellitylimidoglycine). IR and 1H NMR spectroscopy confirmed the copolymer structures. DSC analysis showed that these polyanhydrides have low Tg and low crystallinity. In vitro degradation tests indicated that introducing PEG segments accelerated the degradation rate of these polymers and the degradation duration could be manipulated from 3 days to 3 weeks. The pH of the environment caused by the polymer degradation was lower than 5.0; therefore, the polyanhydrides could be used as components of a newly designed pulsed‐release device for peptide and protein delivery. © 1999 Society of Chemical Industry