Effect of increased knee joint pressure on oxygen tension and blood flow in subchondral bone

We have investigated the influence of acute changes in the knee joint pressure of rabbits on the oxygen tension and the regional blood flow in the subchondral bone. The intra-articular pressure was increased by infusion of a sodium chloride solution into the joint cavity, and the associated change i...

Full description

Saved in:
Bibliographic Details
Published inActa physiologica Scandinavica Vol. 121; no. 2; p. 127
Main Authors Grønlund, J, Kofoed, H, Svalastoga, E
Format Journal Article
LanguageEnglish
Published England 01.06.1984
Subjects
Animals
Bone and Bones - blood supply
Knee Joint - physiology
Mass Spectrometry
Oxygen
Partial Pressure
Pressure
Rabbits
Regional Blood Flow
Online AccessGet more information

Cover

More Information
Summary:We have investigated the influence of acute changes in the knee joint pressure of rabbits on the oxygen tension and the regional blood flow in the subchondral bone. The intra-articular pressure was increased by infusion of a sodium chloride solution into the joint cavity, and the associated change in the subchondral oxygen tension was measured by mass spectrometry. The mass spectrometer was also used to detect, qualitatively, changes in the regional blood flow. When the joint pressure was increased from the habitual level to 75 mmHg, the average subchondral oxygen tension was reduced from about 39 to about 30 mmHg and, at the same time, the regional blood flow was reduced significantly.
ISSN:0001-6772
DOI:10.1111/j.1748-1716.1984.tb07438.x