Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence

• Published in: European journal of clinical investigation Vol. 42; no. 9; pp. 992 - 999
• Main Authors: Masuda, Daisaku, Sugimoto, Taizo, Tsujii, Ken-ichi, Inagaki, Miwako, Nakatani, Kazuhiro, Yuasa-Kawase, Miyako, Tsubakio-Yamamoto, Kazumi, Ohama, Tohru, Nishida, Makoto, Ishigami, Masato, Kawamoto, Toshiharu, Matsuyama, Akifumi, Sakai, Naohiko, Komuro, Issei, Yamashita, Shizuya
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2012; Wiley-Blackwell
• Subjects: Aged; Apolipoprotein B-48; Apolipoprotein B-48 - blood; Biological and medical sciences; Cardiology. Vascular system; chylomicrons; coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - physiopathology; Coronary heart disease; Epidemiology; Fasting; Female; General aspects; Heart; Humans; Hyperglycemia - blood; Lipids - blood; Male; Medical sciences; Middle Aged; postprandial hyperlipidemia; Postprandial Period; Prevalence; Public health. Hygiene; Public health. Hygiene-occupational medicine; remnant lipoproteins; Risk Factors; Statistics as Topic; coronary artery disease; Correlation; Fasting; Prevalence; Postprandial; Metabolic diseases; Cardiovascular disease; Lipids; Lipoprotein; Apolipoprotein B-48; Coronary heart disease; Epidemiology; Apolipoprotein B; Medicine; Persistence; postprandial hyperlipidemia; Chylomicron; Serum; Hyperlipemia; Dyslipemia; Fast; chylomicrons; remnant lipoproteins
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1111/j.1365-2362.2012.02687.x

Eur J Clin Invest 2012; 42 (9): 992–999 Background  Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM‐R). Many in vitro studies have shown that CM‐R has highly atherogenic properties, but consensus is lacking on whether CM‐R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM‐R accumulation and the prevalence of coronary artery disease (CAD). Design  Subjects who received a coronary angiography and did not take any lipid‐lowering drugs (n = 189) were enrolled. Subjects with coronary artery stenosis (≥ 75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B‐48 concentration were compared between CAD patients (n = 96) and age‐, sex‐, and body mass index (BMI)‐matched non‐CAD subjects without overt coronary stenosis (< 75%) (n = 67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B‐48 and other coronary risk factors (high triglyceride, low HDL‐C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results  Fasting serum apo B‐48 levels were significantly higher in CAD patients than in non‐CAD subjects (3·9 ± 2·4 vs. 6·9 ± 2·6 μg/mL, P < 0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B‐48 levels (> 4·34 μg/mL, the cut‐off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B‐48 levels. Conclusion  Fasting serum apo B‐48 levels significantly correlated with the prevalence of CAD.