Identification of two new HLA-DRB1 alleles, DRB1040405 and DRB11190

• Published in: International journal of immunogenetics Vol. 37; no. 5; pp. 397 - 398
• Main Authors: Mantovani, M., Longhi, E., Frison, S., De Arias, A. Espadas, Mosca, A., Poli, F.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2010
• Subjects: Alleles; Base Sequence; Codons; Drb1 protein; Exons; Histocompatibility antigen HLA; Histocompatibility Testing; HLA-DRB1 Chains - genetics; Humans; Methionine; Molecular Sequence Data; Mutation; Nucleotides; Point mutation; Sequence Analysis; valine

Summary We describe here two novel DRB1 alleles, officially named *040405 and *1190. DRB1*040405 differs from DRB1*0404 for one point mutation at codon 72 with no coding changes. DRB1*1190 is identical to DRB1*110101 except for a nucleotide substitution at codon 24 which causes an aminoacidic mutati...