Identification of two new HLA-DRB1 alleles, DRB1040405 and DRB11190

Summary We describe here two novel DRB1 alleles, officially named *040405 and *1190. DRB1*040405 differs from DRB1*0404 for one point mutation at codon 72 with no coding changes. DRB1*1190 is identical to DRB1*110101 except for a nucleotide substitution at codon 24 which causes an aminoacidic mutati...

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Bibliographic Details
Published inInternational journal of immunogenetics Vol. 37; no. 5; pp. 397 - 398
Main Authors Mantovani, M., Longhi, E., Frison, S., De Arias, A. Espadas, Mosca, A., Poli, F.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.10.2010
Subjects
Alleles
Base Sequence
Codons
Drb1 protein
Exons
Histocompatibility antigen HLA
Histocompatibility Testing
HLA-DRB1 Chains - genetics
Humans
Methionine
Molecular Sequence Data
Mutation
Nucleotides
Point mutation
Sequence Analysis
valine
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Summary:Summary We describe here two novel DRB1 alleles, officially named *040405 and *1190. DRB1*040405 differs from DRB1*0404 for one point mutation at codon 72 with no coding changes. DRB1*1190 is identical to DRB1*110101 except for a nucleotide substitution at codon 24 which causes an aminoacidic mutation from valine to methionine. Over time we have been witnessing the identification of a great number of new HLA alleles. DRB1 allelic variability is mostly present in the second exon and more that 760 alleles have been so far identified. Here, we report the description of two novel DRB1 alleles, named *040405 and *1190, and identified in two Caucasoid subjects.
Bibliography:ark:/67375/WNG-9DLL134Z-B
ArticleID:IJI934
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
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ISSN:1744-3121
1744-313X
DOI:10.1111/j.1744-313X.2010.00934.x